MORPHOLOGICAL FEATURES OF POPLITEAL LYMPH NODES IN WHITE OUTBRED RATS WITH RHEUMATOID ARTHRITIS

Authors

  • Avezov Bakhrom Botirovich Independent Researcher Bukhara State Medical Institute Named After Abu Ali Ibn Sino,23 Gijduvon Street, Bukhara 200118, Republic of Uzbekistan

Keywords:

rheumatoid arthritis, peripheral lymph nodes, Alsian blue, histochemistry, morphometry, glycosaminoglycans, immune response, tissue remodeling.

Abstract

The study investigates age-dependent histochemical and morphometric changes in peripheral lymph nodes of white outbred rats with experimental rheumatoid arthritis. Alsian blue staining revealed reactive-proliferative and reparative processes in young (3-month-old) rats, moderate compensatory activity in middle-aged (12-month-old) rats, and predominance of fibrotic and involutional changes in older (18-month-old) rats. Age-related accumulation of glycosaminoglycans in stroma, trabeculae, and sinus walls reflects chronic inflammation and tissue remodeling. The findings highlight dynamic structural and functional adaptations of lymph nodes in autoimmune pathology, providing insights into immunoregulatory mechanisms and potential therapeutic interventions.

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Published

2026-04-06

Issue

Vol. 4 No. 4 (2026): WOM

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

MORPHOLOGICAL FEATURES OF POPLITEAL LYMPH NODES IN WHITE OUTBRED RATS WITH RHEUMATOID ARTHRITIS. (2026). Web of Medicine: Journal of Medicine, Practice and Nursing , 4(4), 14-18. https://mail.webofjournals.com/index.php/5/article/view/6199